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On the ArenaNet official blog, ArenaNet has announced that they will NOT be at E3, but they will be at San Diego Comic-Con, Gamescom, and PAX in July, August and September 2010 respectively.
The most interesting announcement was that they will have an actual playable demo of Guild Wars 2 at Gamescom which happens between August 19-22, 2010.
“I’m happy to announce that we will unveil the first public hands-on demo of Guild Wars 2 at gamescom in Cologne, Germany!”(Link)